Books people have raved to me about:
The Memory Keeper's Daughter by Kim Edwards
The Poisonwood Bible by Barbara Kingsolver
Love in the Time of Cholera by Gabriel Garcia Marquez
I don't know when I'll get around to these! The list might lengthen but I doubt it'll change much. I own all three of these already.
ADDED 6/4: Water for Elephants by Sara Gruen. Hope to get this through PBS or the library soon.